β-Lactamase induction and resistance to β-lactam antibiotics
نویسندگان
چکیده
منابع مشابه
β-Lactam Antibiotics Renaissance.
Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective. The increasing prevalence of multidrug-resistant bacteria and the progressive withdrawal of pharmaceutical companies from antibiotic research have evoked a strong rea...
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The objective of this study was to determine risk factors for the development of resistance to β-lactams/β-lactamase inhibitors (βL/βLIs) and ertapenem among Bacteroides species bacteremia. We conducted a retrospective case-control study of 101 adult patients with Bacteroides species bacteremia at a 1,051-bed tertiary care medical center. The duration of exposure to βL/βLIs (odds ratio [OR], 1....
متن کاملNovel mechanisms of resistance to β-lactam antibiotics in Haemophilus parainfluenzae: β-lactamase-negative ampicillin resistance and inhibitor-resistant TEM β-lactamases.
OBJECTIVES To determine the mechanisms of resistance to β-lactam antibiotics in clinical isolates of Haemophilus parainfluenzae. METHODS Twenty clinical isolates of H. parainfluenzae with decreased susceptibility to aminopenicillins were examined and compared with a control group of 20 fully susceptible isolates. In this collection, the presence of amino acid substitutions in the transpeptida...
متن کاملDegradation of β-lactam antibiotics
Recent developments in the chemistry and biology of βlactam antibiotics which culminated with the introduction of several clinically useful classical and nonclassical β-lactams have been most thrilling and highly rewarding. While this review touches upon the historical development of β-lactams and their reactivity in a nutshell, it provides an overview of various aspects of chemical and enzymat...
متن کاملOccupational allergy to β-lactam antibiotics
Background Contact urticaria in atopic patients was described by Hannuksela [1], among others, in 1980. It generally appears within 30 min of allergen contact and, in the majority of cases, is restricted to the areas of contact; however, local spread and generalized urticaria in the sense of anaphylaxis are seen. Allergic rhinoconjunctivitis and asthma may also subsequently occur [2]. Von Krogh...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1989
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/23.1.1